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高攝取量腦靶向O-去甲基文拉法辛前體藥物的研究與開發(fā)

成果領域: 精準醫(yī)療

推廣方式:

成果歸屬企業(yè): 吉林大學生命科學學院顧景凱教授科研團隊

成果鑒定時間:

成果介紹

抗抑郁是中樞疾病治療領域最為關注的問題。基于抗抑郁藥O-去甲基文拉法辛（ODV）腦攝取不足的缺陷，項目團隊對其進行了結構設計與優(yōu)化，開發(fā)了ODV酚酯類前體藥物。該前體藥物口服吸收良好、入血后快速透過血腦屏障，在腦組織代謝轉化為母體藥物ODV發(fā)揮作用，藥效學研究其抗抑郁效果可與ODV媲美，但給藥劑量大為降低，臨床應用前景廣闊，未來可期。

成果應用案例介紹

聯(lián)系方式

電話/微信: 13822630888

相關成果

免責聲明 / 網站地圖 / 平臺簡介 / 友情鏈接

郵箱：zeccea@qq.com QQ群：318441538 客服電話：0758-2721389 秘書處電話/微信：13822630888

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000012s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001319s ]
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[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000027s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000014s ]
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[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000249s ]
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[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000013s ]
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[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000684s ]
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[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000021s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000042s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
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[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000039s ]

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